CAR-T cells

Car t cells Agency Consulting firm Experts Specialists Consultancy

CAR-T cells are a remarkable therapeutic innovation of recent years. The Alcimed Healthcare team has been exploring the CAR-T cell therapy market for nearly 10 years and supports its clients in their innovation and development projects for these innovative therapies, in optimizing market access and patient care management.

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    The challenges related to CAR-T cell therapy

    The CAR-T cells market, valued at nearly €700 million in 2019, is experiencing strong growth and could reach €3 billion by 2025. In fact, more than 250 pharmaceutical companies around the world are working on research into chimeric antigen receptor T cells.

    However, while the market is promising, this innovative therapy is not without its challenges for the pharmaceutical industry. These challenges include:

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      How we support you in your projects related to CAR-T cell therapy

      For nearly 10 years, Alcimed has been supporting its clients on many issues related to CAR-T cell therapies in hematology, oncology and more broadly in immunotherapy. Indeed, we have carried out dozens of projects in this field for different stakeholders such as:

      • National, European and international institutions and research centers.
      • European and North American biopharmaceutical and pharmaceutical companies
      • Biotech companies

      The diversity of our clients, of the geographic fields we explore, and the types of projects we carry out, give us a global and in-depth understanding of the issues addressed in the field of CAR-T cell therapies.

      In this context, Alcimed supports its clients in particular in exploring this new ecosystem and in analyzing the place and role of industrial players in terms of a value proposition. We have also supported public institutions to position themselves as European champions of CAR-T cells, but also industrial players to prepare the launch of CAR-T cell products, to understand the scope of CAR-T cells manufacturing possibilities, to evaluate market access opportunities, pricing or reimbursement of these treatments.

      Examples of recent projects carried out for our clients in CAR-T cell therapy

      • Preparation for the launch of a new CAR-T cell therapy in the United States and Europe

        We supported a leading stakeholder in the field of CAR-T cells in preparing for the launch of its new treatment and in defining its market access strategy in the United States, Canada and Europe.
        CAR-T cells are highly personalized technologies that require a high level of specialization to be delivered to patients, and therefore not all healthcare ficilities are ready to administer them. In this context, and in order to define the market access strategy for its new treatment, we helped our client to understand and identify which centers would have the capacity to deliver CAR-T cells, among more than 200 care centers in the United States, Canada and Europe.
        Then, the analysis of the barriers to approval in the relevant markets made it possible to define the actions to be implemented to develop the skills of each center, and thus ensure access to their new CAR-T cell therapy.
      • Regulatory framework analysis and market access strategy for a CAR-T cell therapy

        We have supported a global pharmaceutical leader in the characterization of European and American healthcare establishments in order to assess their degree of maturity for the administration of CAR-T cells.
        Thanks to the analysis of the new regulatory framework surrounding the use of CAR-T cells and to the deciphering of the positioning of public healthcare establishments and industrial players in this field, Alcimed enabled its client to better understand the possible regulatory changes as well as the challenges of qualifying centers, defining its market access strategy and adapting its internal structure accordingly.
      • Mapping and analysis of the care pathway for CAR-T cells therapies

        We supported a pharmaceutical company in France in the analysis of the modalities of referral of patients eligible for CAR-T cell therapy to specialized centers.
        We first mapped patient referrals to the 6 major centers of excellence in France for CAR-T cell therapy, then characterized the referral flows (criteria and volumes) and the relationships between peripheral centers and centers of excellence.
        By identifying the criteria for addressing patients and the levers to be activated to promote cooperation and coordination between those involved in the pathway, our client was able to understand the opportunities for improvement and the barriers to be faced in order to guarantee the optimal functioning of the process.
      • Development of the Brand Plan for the launch of two CAR-T cell therapies

        We supported the teams of a pharmaceutical company in France in their preparation for the launch of two CAR-T cell gene therapy products and in defining their brand plan.

        Because of the novelty of these products, it was first of all a matter of challenging and building a shared vision in the team of the launch strategy for these products (medical, marketing, market access, etc.), over the course of several workshops.

        The structuring of these ideas was then a key step in making this vision concrete and operational, and helped accelerate the formalization of the Brand Plan co-constructed by all.

      • Identification of potential Car-T cell options for a rare cancer indication for a pharma player

        Alcimed worked with a big pharma player to identify new potential treatment options in rare cancer, and prioritize them regarding their competitive threat level and their fit to existing portfolio.

        We supported this customer by firstly drawing a map of the current standard of care pathway in the rare cancer indication, understanding involved stakeholders, treatments and decision points. Next, we identified treatment options that possibly impact on this care pathway in the future, notably Car-T cell options. Together with the client we run strategic working sessions in order to assess competitive threat and commercial potential of Car-T cells.

        Using this methodology allowed us to recommend to our client whether or not an addition of Car T-cell to the existing portfolio shall be envisioned.

      • Supporting a pharma player in understanding the Car-T cell market in order to prepare their commercialization strategy

        Alcimed supported a pharma player in understanding the market for allogenic Car-T cells, its market size and future growth potential as wells its implications in various cancer indications.

        We supported the player in gaining understanding the possibilities of development and valorization of their Car-Tcell applications. Also we ran benchmarks to identify past commercialization strategies of other players in the market.

        Our work supported getting a good understanding around the business development potential of their technology as well as building on recommendations regarding partnerships to further develop and commercialize their technology. Likewise we recommended on key next steps to undertake.

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